Open Access

Fabrication and Characterization of Nickel Nanoparticles using Calotropis gigantea for Antimalarial Applications

S. Peer Mohamed peerjamal38@gmail.com
Department of Zoology, Sadakathullah Appa College (Autonomous), Rahmath Nagar, Tirunelveli, TN, India


J. Environ. Nanotechnol., Volume 12, No 1 (2023) pp. 06-10

https://doi.org/10.13074/jent.2023.03.231465

PDF


Abstract

     Malaria diagnosis using sophisticated methods is highly expensive and time-consuming. The development of sensitive, selective, robust, accurate, fast and low-cost clinical diagnosis techniques has been a major focus of researchers in recent years. In this work, nickel nanoparticles have been synthesized successfully using Calotropis gigantea leaf extract, by Co-precipitation method and then characterized by Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), Energy Dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FT-IR) and Ultraviolet-visible (UV-Vis.) spectroscopic techniques. FT-IR spectra showed a sharp peak at 699 cm -1 and a broad peak ranging from 2500 - 3500 cm-1 ensuring the construction of nickel nanoparticles. X-ray Diffraction pattern revealed a face-centered cubic structure. The SEM image has shown the spherical structure with a rough area. The results obtained were satisfactory in terms of antimalarial applications of the nickel nanoparticles.

Full Text

Reference


Alencar, N. M., Figueiredo, I. S., Vale, M. R., Bitencurt, F. S., Oliveira, J. S., Ribeiro, R. A., Ramos, M. V., Anti-inflammatory effect of the latex from Calotropis procera in three different experimental models: Peritonitis, paw edema and hemorrhagic cystitis, Planta Med., 70(12), 1144-1449 (2004). https://doi.org/10.1055/s-2004-835842

Arya, S. and Kumar, V. L., Interleukin 1 beta inhibits paw edema induced by local administration of latex of Calotropis procera extracts, Inflammopharmacology, 12(4), 391-398 (2004).

https://doi.org/10.1163/1568560043696254

Basu, A. and Chaudhuri, A. K. N., Preliminary studies on the anti-inflammatory and analgesic activities of Calotropis procera root extract, J. Ethnopharmacol., 31(3), 319-324 (1991).

https://doi.org/10.1016/0378-8741(91)90017-8

Bhaskar, V. H., and Ajay, S. S., Antimicrobial Activity of Calotropis procera Seeds. Asian journal of chemistry, 21(7), 5788-5790 (2000).

Bhatti, G. R., Qureshi, R. and Shah, M., Ethnobotany of Calotropis procera with especial reference to the people of Nara Desert, Scientific Sindh., 5, 13-22 (1998).

Chatterjee, A. and Chandra, P. S., The treatise of Indian medicinal plants, CSIR, Volume 4, 130 (1995).

Dewan S., Kumar, S. and kumar, V. L., Antipyretic effect of latex of Calotropis procera, Indian J. Pharmacol., 32(3), 252-253 (2000).

Elisabetsky, E., Castilhos, Z. C., Plants used as analgesics by Amazonian cabocols, Int. J. Crude Drug Res., 28(4), 309-320 (1990). https://doi.org/10.3109/13880209009082838

Ghosh, N. C., Comparative Materia Medica, Calcutta: Hannemann Publ. Co. Pvt. Ltd, (1988).

Harne, S., Sharma, A., Dhaygude, M., Joglekar, S., Kodam, K. and Hudlikar, M., Novel route for rapid biosynthesis of copper nanoparticles using aqueous extract of Calotropis procera L. latex and their cytotoxicity on tumor cells, Colloids Surf B: Biointerfaces, 95, 284-288 (2012).

https://doi.org/10.1016/j.colsurfb.2012.03.005

Kumar, V. L. and Arya, S., Medicinal uses and pharmacological properties of Calotropis procera, Recent Prog. in Med. Plants, 373-388 (2006).

Mukherjee, B., Bose, S. and Dutta, S. K., Phytochemical and pharmacological investigation of fresh flower extract of Calotropis procera Linn, Int. J. Pharm. Sci. Res., 1(2), 182-187 (2010).

http://dx.doi.org/10.13040/IJPSR.0975-8232.1(12).182-87

Oudhia, P. C., Useful weed, society for panthenium management, Geeta nagar, India (2001).

Quaquebeke, V. E., Simon, G., Andre, A., Dewelle, J., Yazidi, M. E., Bruyneel, F., Jerome, T., Odile, N., Pierre, G., Christine, D., Jean-Claude, B., Robert, K., Francis, D., Identification of a novel cardenolide (2-oxovoruscharin) from Calotropis procera and the hemi-synthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: Structure-activity relationship analyses, J. Med. Chem., 48, 849-856 (2005).

https://doi.org/10.1021/jm049405a

Ramos, M. V., Viana, C. A., Silva, A. F., Freitas, C. D., Figueiredo, I. S., Oliveira, R. S., Alencar, N. M., Lima-Filho, J. V., Kumar V. L., Proteins derived from latex of C. procera maintain coagulation homeostasis in septic mice and exhibit thrombin and plasmin-like activities, Naunyn Schmiedebergs Arch Pharmacol., 385(5), 455-463 (2012).

https://doi.org/10.1007/s00210-012-0733-3

Sameer, H. Q. M., DNA-RAPD Fingerprinting and Cytogenetic Screening of Genotoxic and Antigenotoxic Effects of Aqueous Extracts of Costus Speciosus (Koen.), JKAU: Sci., 22(1), 133-152 (2010).

Sangraula, H., Dewan, S., Kumar, V. L., Evaluation of the anti-inflammatory activity of latex of Calotropis procera in different models of inflammation, Inflammopharmacology, 9, 257-64 (2002).

Saxena, V. K. and Saxena, Y. P., Isolation and study of triterpenoids from Calotropis procera, J. Res. Indian Med. Yoga Homeopathy., 14, 152-154 (1979).

Sharma, P. and Sharma, J. D., In-vitro Schizontocidal screening of Calotropis procera, Fitoterapia, 71(1), 77-79 (2000).

https://doi.org/10.1016/s0367-326x(99)00121-5

Shinwari, M. I. and Khan, M. A., Folk use of medicinal herbs of Margalla hills national park, Islamabad, J. Ethnopharmacol., 69(1), 45-56 (2000).

https://doi.org/10.1016/s0378-8741(99)00135-x

Taylor, P., Arsenak, M., Abad, M. J., Fernández, A., Milano, B., Gonto, R., Screening of Venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumor cell lines, Phytother Res., 27, 530-539 (2013).

https://doi.org/10.1002/ptr.4752

Yelne, M. B.,Sharma, P. C. and Dennis, T. J., Database on Medicina Plants used in Ayurveda, Central Council for Research in Ayurveda and Siddha, New-Delhi., 2, 69-73 (2000).

Contact Us

  • No. 53, II Street,
    Rock Mount City, Erode,
    TN, India - 638112
  • editorjent@gmail.com
  • +91 94422 64501

Powered by

Powered by OJS