A Comprehensive Review on Recent Advances in Chitosan and Graphene Oxide Nanocomposites for Environmental, Biomedical and Smart Material Applications
J. Environ. Nanotechnol., Volume 15, No 3 (September 2026) pp. 924-964
Abstract
Chitosan–graphene oxide (CS–GO) nanocomposites combine the biodegradability, biocompatibility, cationic character, and film-forming ability of chitosan with the high surface area, oxygen-rich functionality, mechanical reinforcement, and tunable physicochemical properties of graphene oxide, enabling applications in environmental remediation, biomedical engineering, food packaging, sensing, and smart materials. This review critically examines recent advances in CS–GO preparation, interfacial chemistry, characterization, structure–property relationships, sustainability, scale-up, and application performance, with particular emphasis on chitosan molecular weight and degree of deacetylation, GO oxidation level and loading, dispersion, cross-linking, and processing conditions. Hydrogen bonding, electrostatic attraction, covalent coupling, coordination, and π–π interactions govern CS–GO assembly and strongly influence mechanical, adsorption, biological, barrier, electrical, and multifunctional behavior. Environmental remediation and biomedical applications currently have the strongest evidence base, while emerging uses include microplastic capture, desalination, sensing, supercapacitors, proton-exchange membranes, and hydrogen-generation catalysis. Key challenges include inconsistent characterization, limited real-matrix validation, regeneration cost, nanoparticle migration, long-term toxicity, life-cycle impacts, and scalable green manufacturing. Future translation requires standardized characterization, application-specific safety assessment, real-world validation, life-cycle evaluation, and reproducible large-scale fabrication.
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Reference
Abbasian, M., Roudi, M. M., Mahmoodzadeh, F., Eskandani, M. and Jaymand, M., Chitosan-grafted-poly(methacrylic acid)/graphene oxide nanocomposite as a pH-responsive de novo cancer chemotherapy nanosystem, Int. J. Biol. Macromol., 118, 1871–1879 (2018).
https://doi.org/10.1016/j.ijbiomac.2018.07.036
Adetayo, A. and Runsewe, D., Synthesis and fabrication of graphene and graphene oxide: A review, Open J. Compos. Mater., 9(2), 207–229 (2019).
https://doi.org/10.4236/ojcm.2019.92012
Adonis, S., Van der Horst, C. and Somerset, V., Environmental and industrial application of chitosan nanocomposites: Review, Discov. Chem., 3(1), 105 (2026).
https://doi.org/10.1007/s44371-026-00530-x
Ahmed, J., Mulla, M., Arfat, Y. A. and Thai, T. L. A., Mechanical, thermal, structural and barrier properties of crab shell chitosan/graphene oxide composite films, Food Hydrocoll., 71, 141–148 (2017).
https://doi.org/10.1016/j.foodhyd.2017.05.013
Ahmed, M. A., Ahmed, M. A. and Mohamed, A. A., Synthesis, characterization and application of chitosan/graphene oxide/copper ferrite nanocomposite for adsorptive removal of anionic and cationic dyes from wastewater, RSC Adv., 13(8), 5337–5352 (2023).
https://doi.org/10.1039/D2RA07883J
Akbari, H. H. R. and Zarei, K., DNA/Au-Pt bimetallic nanoparticles/graphene oxide-chitosan composites modified pencil graphite electrode used as an electrochemical biosensor for sub-picomolar detection of anti-HIV drug zidovudine, Microchem. J., 164, 106005 (2021).
https://doi.org/10.1016/j.microc.2021.106005
Ali, M., Sholkamy, E. N., Alobaidi, A. S., Al-Muhanna, M. K. and Barakat, A., Synthesis of Schiff bases based on chitosan and heterocyclic moiety: Evaluation of antimicrobial activity, ACS Omega, 8(49), 47304–47312 (2023).
https://doi.org/10.1021/acsomega.3c08446
Bai, H., Li, Y., Zhang, H., Chen, H., Wu, W., Wang, J. and Liu, J., Anhydrous proton exchange membranes comprising of chitosan and phosphorylated graphene oxide for elevated temperature fuel cells, J. Membr. Sci., 495, 48–60 (2015).
https://doi.org/10.1016/j.memsci.2015.08.012
Bao, H., Pan, Y., Ping, Y., Sahoo, N. G., Wu, T., Li, L., Li, J. and Gan, L. H., Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery, Small, 7(11), 1569–1578 (2011).
https://doi.org/10.1002/smll.201100191
Barrowclough, D. and Birkbeck, C. D., Transforming the global plastics economy: The role of economic policies in the global governance of plastic pollution, Soc. Sci., 11(1), 26 (2022).
https://doi.org/10.3390/socsci11010026
Bulin, C. and Guo, T., Ultra fast and highly efficient recovery of cadmium with graphene oxide-chitosan grafted by nickel ferrite as a recyclable adsorbent and atomic scale mechanism, Sci. Total Environ., 991, 179974 (2025).
https://doi.org/10.1016/j.scitotenv.2025.179974
Chadha, N., Bhat, M. Y., Hashmi, S. A. and Saini, P., Fe3O4/graphene-oxide/chitosan hybrid aerogel based high-performance supercapacitor: Effect of aqueous electrolytes on storage capacity and cell stability, J. Energy Storage, 46, 103789 (2022).
https://doi.org/10.1016/j.est.2021.103789
Chang, Y., Yang, S. T. and Liu, J. H., In vitro toxicity evaluation of graphene oxide on A549 cells, Toxicol. Lett., 200, 201–210 (2011).
https://doi.org/10.1016/j.toxlet.2010.11.016
Chen, S., Wang, H., Jian, Z., Fei, G., Qian, W., Luo, G., Wang, Z. and Xia, H., Novel poly(vinyl alcohol)/chitosan/modified graphene oxide biocomposite for wound dressing application, Macromol. Biosci., 20(3), 1900385 (2020).
https://doi.org/10.1002/mabi.201900385
Cobos, M., González, B., Fernández, M. J. and Fernández, M. D., Chitosan–graphene oxide nanocomposites: Effect of graphene oxide nanosheets and glycerol plasticizer on thermal and mechanical properties, J. Appl. Polym. Sci., 134(30), 45092 (2017).
https://doi.org/10.1002/app.45092
Croitoru, A. M., Ficai, A., Ficai, D., Trusca, R., Dolete, G., Ecaterina, A. and Stefan, T. C., Chitosan/graphene oxide nanocomposite membranes as adsorbents with applications in water purification, Mater., 13(7), 1687 (2020).
https://doi.org/10.3390/ma13071687
de Jong, E., Goumans, I., Visser, R., Puente, Á. and Gruter, G. J., The opportunities and challenges of biobased packaging solutions, Polym., 17(16), 2217 (2025).
https://doi.org/10.3390/polym17162217
Dinescu, S., Ionita, M., Ignat, S. R., Costache, M. and Hermenean, A., Graphene oxide enhances chitosan-based 3D scaffold properties for bone tissue engineering, Int. J. Mol. Sci., 20(20), 5077 (2019).
https://doi.org/10.3390/ijms20205077
El-Sheikh, A. S., Abdelaziz, N. S., Amin, K. S., Elhaes, H. and Ibrahim, M. A., Application of chitosan/graphene and chitosan/graphene oxide composites for removal of Cu and Pb, Sci. Rep., 15(1), 28905 (2025).
https://doi.org/10.1038/s41598-025-13307-6
Emadi, F., Amini, A., Gholami, A. and Ghasemi, Y., Functionalized graphene oxide with chitosan for protein nanocarriers to protect against enzymatic cleavage and retain collagenase activity, Sci. Rep., 7(1), 42258 (2017).
https://doi.org/10.1038/srep42258
Fayyad, E. M., Sadasivuni, K. K., Ponnamma, D. and Al-Maadeed, M. A. A., Oleic acid-grafted chitosan/graphene oxide composite coating for corrosion protection of carbon steel, Carbohydr. Polym., 151, 871–878 (2016).
https://doi.org/10.1016/j.carbpol.2016.06.001
Fazial, F. F. and Tan, L. L., Phenylalanine-responsive fluorescent biosensor based on graphene oxide–chitosan nanocomposite catalytic film for non-destructive fish freshness grading, Food Control, 125, 107995 (2021).
https://doi.org/10.1016/j.foodcont.2021.107995
Feng, W. and Wang, Z., Biomedical applications of chitosan–graphene oxide nanocomposites, iSci., 25(1), 103629 (2022).
https://doi.org/10.1016/j.isci.2021.103629
Figueroa, T., Aguayo, C. and Fernández, K., Design and characterization of chitosan–graphene oxide nanocomposites for the delivery of proanthocyanidins, Int. J. Nanomed., 15, 1229–1238 (2020).
https://doi.org/10.2147/IJN.S240305
Francolini, I., Perugini, E., Silvestro, I., Lopreiato, M., Anna, S. A., Federica, V., Placidi, E., Fabrizio, A., Andrea, M. and Piozzi, A., Graphene oxide oxygen content affects physical and biological properties of scaffolds based on chitosan/graphene oxide conjugates, Mater., 12(7), 1142 (2019).
https://doi.org/10.3390/ma12071142
Grande, C. D., Mangadlao, J., Fan, J., Leon, D. A., Johannes, D. O., Rojas, J. G., Debora, R. F. and Advincula, R., Chitosan cross-linked graphene oxide nanocomposite films with antimicrobial activity for application in food industry, Macromol. Symp., 374(1), 1600114 (2017).
https://doi.org/10.1002/masy.201600114
Hermenean, A., Codreanu, A., Herman, H., Balta, C., Rosu, M., Mihali, C. V., Ivan, A., Dinescu, S., Ionita, M. and Costache, M., Chitosan-graphene oxide 3D scaffolds as promising tools for bone regeneration in critical-size mouse calvarial defects, Sci. Rep., 7(1), 16641 (2017).
https://doi.org/10.1038/s41598-017-16599-5
Jafari, Z., Rad, A. S., Baharfar, R., Asghari, S., Esfahani, M. R., Synthesis and application of chitosan/tripolyphosphate/graphene oxide hydrogel as a new drug delivery system for Sumatriptan Succinate, J. Mol. Liq., 315, 113835 (2020).
https://doi.org/10.1016/j.molliq.2020.113835
Jiang, C., Gao, M., Zhang, S., Huang, L., Yu, S., Song, Z. and Wu, Q., Chitosan/graphene oxide hybrid hydrogel electrode with porous network boosting ultrahigh energy density flexible supercapacitor, Int. J. Biol. Macromol., 225, 1437–1448 (2023).
https://doi.org/10.1016/j.ijbiomac.2022.11.201
Jiménez-Gómez, C. P. and Cecilia, J. A., Chitosan: A natural biopolymer with a wide and varied range of applications, Mol., 25(17), 3981 (2020).
https://doi.org/10.3390/molecules25173981
Kanted, D., Soman, V., Sahota, S. and Poddar, M. K., Development of hybrid chitosan/zinc oxide/graphene oxide nanocomposites for potential food packaging application, Int. J. Sustain. Build. Technol. Urban Dev., 14(1), 96–110 (2023).
https://doi.org/10.22712/susb.20230008
Katas, H., Mohd Amin, M. C. I., Moideen, N., Ng, L. Y., Megat, B. P. A. A., Cell growth inhibition effect of DsiRNA vectorised by pectin-coated chitosan-graphene oxide nanocomposites as potential therapy for colon cancer, J. Nanomater., 2017, 1–12 (2017).
https://doi.org/10.1155/2017/4298218
Khandegar, V., Kaur, P. J. and Chanana, P., Chitosan and graphene oxide-based nanocomposites for water purification and medical applications: A review, BioRes., 16(4), 8525–8566 (2021).
https://doi.org/10.15376/biores.16.4.Khandegar
Kolanthai, E., Sindu, P. A., Khajuria, D. K., Veerla, S. C., Kuppuswamy, D., Catalani, L. H. and Mahapatra, D. R., Graphene oxide—A tool for the preparation of chemically crosslinking-free alginate–chitosan–collagen scaffolds for bone tissue engineering, ACS Appl. Mater. Interf., 10(15), 12441–12452 (2018).
https://doi.org/10.1021/acsami.8b00699
Kress, L., Schmid, C., Manshoven, S., Van, O. W., Tom, D., Lars, M. F., Tobias, N. and Juliana, S. L., Scaling of Circular Business Models in Europe’s Circular Economy, Europ. Topic Centre Knowl. Hub, (2026).
https://doi.org/10.5281/zenodo.19669109
Kumar, G., Chaudhary, K., Mogha, N. K., Kant, A. and Masram, D. T., Extended Release of Metronidazole Drug Using Chitosan/Graphene Oxide Bionanocomposite Beads as the Drug Carrier, ACS Omega, 6(31), 20433–20444 (2021).
https://doi.org/10.1021/acsomega.1c02422
Kumari, P., Kumar, A., Yadav, A., Sabri, Y., Ippolito, S. J., Shivagan, D. D. and Bapna, K., High performance humidity sensor based on a graphene oxide–chitosan composite, Phys. Chem. Chem. Phys., 27(6), 3420–3429 (2025).
https://doi.org/10.1039/D4CP04347B
Li, W., Jiang, T., Pu, Y., Jiao, X., Tan, W. and Qin, S., Glucose biosensor using fluorescence quenching with chitosan-modified graphene oxide, Micro Nano Lett., 14(3), 344–348 (2019).
https://doi.org/10.1049/mnl.2018.5269
Liang, Y., Wang, M., Zhang, Z., Ren, G., Liu, Y., Wu, S. and Shen, J., Facile synthesis of ZnO QDs@GO-CS hydrogel for synergetic antibacterial applications and enhanced wound healing, Chem. Eng. J., 378, 122043 (2019).
https://doi.org/10.1016/j.cej.2019.122043
Liu, H., Wang, C., Li, C., Qin, Y., Wang, Z., Yang, F., Li, Z. and Wang, J., A functional chitosan-based hydrogel as a wound dressing and drug delivery system in wound healing, RSC Adv., 8(14), 7533–7549 (2018).
https://doi.org/10.1039/C7RA13510F
Liu, S., Chen, X., Wu, Z.-J., Zheng, X.-C., Peng, Z.-K. and Liu, P., Chitosan-reduced graphene oxide hybrids encapsulated Pd(0) nanocatalysts for H2 generation from ammonia borane, Int. J. Hydrogen Energy, 44(42), 23610–23619 (2019).
https://doi.org/10.1016/j.ijhydene.2019.07.088
Lu, Y. J., Lan, Y. H., Chuang, C. C., Lu, W. T., Chan, L. Y., Hsu, P. W. and Chen, J. P., Injectable thermo-sensitive chitosan hydrogel containing CPT-11-loaded EGFR-targeted graphene oxide and SLP2 shRNA for localized drug/gene delivery in glioblastoma therapy, Int. J. Mol. Sci., 21(19), 7111 (2020).
https://doi.org/10.3390/ijms21197111
Ma, L., Feng, X., Liang, H., Wang, K., Yu, S., Lei, T., Wang, B., Luo, R., Liao, Z., Li, G., Liu, X., Wu, S. and Cao, Y., A novel photothermally controlled multifunctional scaffold for osteosarcoma treatment and tissue regeneration, Mater. Today, 36, 48–62 (2020).
https://doi.org/10.1016/j.mattod.2019.12.005
Mahanty, B., Grover, V., Hussain, S. and Hait, S., A green biopolymer-functionalized graphene oxide adsorbent for the efficient removal of perfluorooctanoic acid from water, Process Saf. Environ. Prot., 211, 108767 (2026).
https://doi.org/10.1016/j.psep.2026.108767
Mahmoudi, N., Eslahi, N., Mehdipour, A., Mohammadi, M., Akbari, M., Samadikuchaksaraei, A. and Simchi, A., Temporary skin grafts based on hybrid graphene oxide–natural biopolymer nanofibers as effective wound-healing substitutes, J. Mater. Sci. Mater. Med., 28(5), 73 (2017).
https://doi.org/10.1007/s10856-017-5874-y
Majidi, H. J., Mirzaee, A., Jafari, S. M., Amiri, M., Shahrousvand, M. and Babaei, A., Fabrication and characterization of graphene oxide-chitosan-zinc oxide ternary nano-hybrids for the corrosion inhibition of mild steel, Int. J. Biol. Macromol., 148, 1190–1200 (2020).
https://doi.org/10.1016/j.ijbiomac.2019.11.060
Massey, D. D., Verghese, P. S., Habil, M. and Saraswat, R. K., Innovative Approaches in Nanomaterials for Efficient Heavy Metal Removal from Wastewater: A Scientific Review, J. Environ. Nanotechnol., 13(4), 518–526 (2024).
https://doi.org/10.13074/jent.2024.12.2441022
Marnani, N. N. and Shahbazi, A., A novel environmental-friendly nanobiocomposite synthesis by EDTA and chitosan functionalized magnetic graphene oxide for high removal of Rhodamine B: Adsorption mechanism and separation property, Chemosphere, 218, 715–725 (2019).
https://doi.org/10.1016/j.chemosphere.2018.11.109
Mehdizadeh, B., Maleknia, L., Amirabadi, A. and Shabani, M., Glucose sensing by a glassy carbon electrode modified with glucose oxidase/chitosan/graphene oxide nanofibers, Diamond Relat. Mater., 109, 108073 (2020).
https://doi.org/10.1016/j.diamond.2020.108073
Moradi, S., Hamedi, H., Tonelli, A. E. and King, M. W., Chitosan/graphene oxide composite films and their biomedical and drug delivery applications: A review, Appl. Sci., 11(17), 7776 (2021).
https://doi.org/10.3390/app11177776
Najafabadi, S. A. A., Mohammadi, A. and Kharazi, A. Z., Polyurethane nanocomposite impregnated with chitosan-modified graphene oxide as a potential antibacterial wound dressing, Mater. Sci. Eng. C, 115, 110899 (2020).
https://doi.org/10.1016/j.msec.2020.110899
Naser, H. N., Fadhil, M. A., Hassoun, T. A. Z., Ahmed, R. T. and Al-Nafiey, A., Green synthesis of novel chitosan–graphene oxide–silver nanoparticle nanocomposite for broad-spectrum antibacterial applications, Oxford Open Mater. Sci., 5(1), itae018 (2025).
https://doi.org/10.1093/oxfmat/itae018
Prokhorov, E. and Luna-Bárcenas, G., Negative electrical tunability of chitosan–graphene oxide nanocomposites, Appl. Phys. A, 126(12), 934 (2020).
https://doi.org/10.1007/s00339-020-04119-8
Promkatkaew, M., Srisuratsiri, P., Sangpanich, U., Kullawadee, S. and Sunan, K., Graphene oxide–chitosan composite for efficient adsorptive removal of Cu(II), Co(II), and Ni(II) from simulated E-waste effluents, ACS Omega, 10(38), 44111–44124 (2025).
https://doi.org/10.1021/acsomega.5c05350
Qian, X., Li, N., Wang, Q. and Ji, S., Chitosan/graphene oxide mixed matrix membrane with enhanced water permeability for high-salinity water desalination by pervaporation, Desalin., 438, 83–96 (2018).
https://doi.org/10.1016/j.desal.2018.03.031
Rajput, P. and Khanchandani, S., A review of chitosan-functionalized graphene oxide nanocomposites: A revolutionary drug delivery vehicle for cancer therapy, Int. J. Biol. Macromol. 311, 143999 (2025).
https://doi.org/10.1016/j.ijbiomac.2025.143999
Ramamurthy, M., Vasanthkumar, P., Perumal, G., Senthilkumar, N., Formulation and Features of Chitosan and Natural Fiber Blended Bio-composite towards Environmental Sustainability, J. Environ. Nanotechnol., 14(1), 104–112 (2025).
https://doi.org/10.13074/jent.2025.03.243932
Rasoulzadehzali, M. and Namazi, H., Facile preparation of antibacterial chitosan/graphene oxide-Ag bio-nanocomposite hydrogel beads for controlled release of doxorubicin, Int. J. Biol. Macromol., 116, 54–63 (2018).
https://doi.org/10.1016/j.ijbiomac.2018.04.140
Rinaudo, M., Chitin and chitosan: Properties and applications, Prog. Polym. Sci., 31(7), 603–632 (2006).
https://doi.org/10.1016/j.progpolymsci.2006.06.001
Sabzevari, M., Cree, D. E. and Wilson, L. D., Graphene oxide–chitosan composite material for treatment of a model dye effluent, ACS Omega, 3(10), 13045–13054 (2018).
https://doi.org/10.1021/acsomega.8b01871
Saputra, A. M. A. and Agustina, N., Amran, Zurnansyah, Samnur and Hadi, S. E., Synthesis and characterisation of graphene oxide/chitosan composite membranes from natural waste, J. Phys. Sci., 33(3), 63–79 (2022).
https://doi.org/10.21315/jps2022.33.3.5
Saravanan, S., Chawla, A., Vairamani, M., Sastry, T. P., Subramanian, K. S. and Selvamurugan, N., Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo, Int. J. Biol. Macromol., 104, 1975–1985 (2017).
https://doi.org/10.1016/j.ijbiomac.2017.01.034
Saravanan, S., Vimalraj, S. and Anuradha, D., Chitosan based thermoresponsive hydrogel containing graphene oxide for bone tissue repair, Biomed. Pharmacother., 107, 908–917 (2018).
https://doi.org/10.1016/j.biopha.2018.08.072
Shahbazmohammadi, H., Sardari, S. and Omidinia, E., An amperometric biosensor for specific detection of glycated hemoglobin based on recombinant engineered fructosyl peptide oxidase, Int. J. Biol. Macromol., 142, 855–865 (2020).
https://doi.org/10.1016/j.ijbiomac.2019.10.025
Shirdast, A., Sharif, A. and Abdollahi, M., Effect of the incorporation of sulfonated chitosan/sulfonated graphene oxide on the proton conductivity of chitosan membranes, J. Power Sources, 306, 541–551 (2016).
https://doi.org/10.1016/j.jpowsour.2015.12.076
Song, J. H., Murphy, R. J., Narayan, R. and Davies, G. B. H., Biodegradable and compostable alternatives to conventional plastics, Philos. Trans. R. Soc. B Biol. Sci., 364(1526), 2127–2139 (2009).
https://doi.org/10.1098/rstb.2008.0289
Su, Z., Sun, D., Zhang, L., He, M., Jiang, Y., Millar, B., Paula, D., Davide, M., Paul, M. and Sun, D., Chitosan/silver nanoparticle/graphene oxide nanocomposites with multi-drug release, antimicrobial, and photothermal conversion functions, Mater., 14(9), 2351 (2021).
https://doi.org/10.3390/ma14092351
Sun, Y. Y., Li, W., Li, M., Sun, Y. Y., Lu, H. Q., Xiong, Y. S. and Dong, H., Chitosan/graphene oxide composite aerogel based on bionic-design of morning glories for artificial sweetener remediation: Exploring novel adsorption mechanisms and sustainable applications, Food Chem., 516, 149294 (2026).
https://doi.org/10.1016/j.foodchem.2026.149294
Tran, H. V., Bui, L. T., Dinh, T. T., Le, D. H., Huynh, C. D. and Trinh, A. X., Graphene oxide/Fe₃O₄/chitosan nanocomposite: A recoverable and recyclable adsorbent for organic dye removal, Mater. Res. Exp., 4(3), 035701 (2017).
https://doi.org/10.1088/2053-1591/aa6096
Travlou, N. A., Kyzas, G. Z., Lazaridis, N. K. and Deliyanni, E. A., Graphite oxide/chitosan composite for reactive dye removal, Chem. Eng. J., 217, 256–265 (2013).
https://doi.org/10.1016/j.cej.2012.12.008
Valencia-Llano, C. H., Solano, M. A. and Grande-Tovar, C. D., Nanocomposites of chitosan/graphene oxide/titanium dioxide nanoparticles/blackberry waste extract as potential bone substitutes, Polym., 13(22), 3877 (2021).
https://doi.org/10.3390/polym13223877
Vo, L. Q., Vu, A. T., Le, T. D., Huynh, C. D. and Tran, H. V., Fe₃O₄/graphene oxide/chitosan nanocomposite: A smart nanosorbent for lead(II) ion removal from contaminated water, ACS Omega, 9, 17506–17517 (2024).
https://doi.org/10.1021/acsomega.4c00486
Wang, C., Zhang, Z., Chen, B., Gu, L., Li, Y. and Yu, S., Design and evaluation of galactosylated chitosan/graphene oxide nanoparticles as a drug delivery system, J. Colloid Interf. Sci., 516, 332–341 (2018).
https://doi.org/10.1016/j.jcis.2018.01.073
Wang, Y., Liu, S. and Yu, W., Functionalized graphene oxide-reinforced chitosan hydrogel as biomimetic dressing for wound healing, Macromol. Biosci., 21(4), 2000432 (2021).
https://doi.org/10.1002/mabi.202000432
Wei, H., Han, L., Tang, Y., Ren, J., Zhao, Z. and Jia, L., Highly flexible heparin-modified chitosan/graphene oxide hybrid hydrogel as a super bilirubin adsorbent with excellent hemocompatibility, J. Mater. Chem. B, 3(8), 1646–1654 (2015).
https://doi.org/10.1039/C4TB01673D
Wu, T., Li, B., Wang, W., Chen, L., Li, Z., Wang, M., Zha, Z., Lin, Z., Xia, H. and Zhang, T., Strontium-substituted hydroxyapatite grown on graphene oxide nanosheet-reinforced chitosan scaffold to promote bone regeneration, Biomater. Sci., 8(16), 4603–4615 (2020).
https://doi.org/10.1039/D0BM00523A
Xu, S., Zhang, Y., Dong, K., Wen, J., Zheng, C. and Zhao, S., Electrochemical DNA biosensor based on graphene oxide-chitosan hybrid nanocomposites for detection of Escherichia coli O157:H7, Int. J. Electrochem. Sci., 12(4), 3443–3458 (2017).
https://doi.org/10.20964/2017.04.16
Xue, J., Feng, C., Xia, L., Zhai, D., Ma, B., Wang, X., Fang, B., Chang, J. and Wu, C., Assembly preparation of multilayered biomaterials with high mechanical strength and bone-forming bioactivity, Chem. Mater., 30(14), 4646–4657 (2018).
https://doi.org/10.1021/acs.chemmater.8b01272
Xue, J., Wang, X., Wang, E., Li, T., Chang, J. and Wu, C., Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing, Acta Biomater., 100, 270–279 (2019).
https://doi.org/10.1016/j.actbio.2019.10.012
Yakout, A. A., Badr El-din, A. S., Al Solami, A., Aljadaani, A. H., Amino–MIL-101(Fe)/Chitosan–Graphene Oxide Cross-Linked Nanocomposite for High-Performance Adsorptive Remediation of Wastewater Microplastics from Environmental Samples, Polym., 18(7), 878 (2026).
https://doi.org/10.3390/polym18070878
Yan, H., Cordier, M. and Uehara, T., Future projections of global plastic pollution: Scenario analyses and policy implications, Sustainability, 16(2), 643(2024).
https://doi.org/10.3390/su16020643
Yang, S., Lei, P., Shan, Y. and Zhang, D., Preparation and characterization of antibacterial electrospun chitosan/poly(vinyl alcohol)/graphene oxide composite nanofibrous membrane, Appl. Surf. Sci., 435, 832–840 (2018).
https://doi.org/10.1016/j.apsusc.2017.11.191
Yang, S., Zhang, X. and Zhang, D., Electrospun chitosan/poly(vinyl alcohol)/graphene oxide nanofibrous membrane with ciprofloxacin antibiotic drug for potential wound-dressing application, Int. J. Mol. Sci., 20(18), 4395 (2019).
https://doi.org/10.3390/ijms20184395
Yang, X., Tu, Y., Li, L., Shang, S. and Tao, X. M., Well-dispersed chitosan/graphene oxide nanocomposites, ACS Appl. Mater. Interf., 2(6), 1707–1713 (2010).
https://doi.org/10.1021/am100222m
Yu, P., Bao, R. Y., Shi, X. J., Yang, W. and Yang, M. B., Self-assembled high-strength hydroxyapatite /graphene oxide /chitosan composite hydrogel for bone tissue engineering, Carbohydr. Polym., 155, 507–515 (2017).
https://doi.org/10.1016/j.carbpol.2016.09.001
Yu, Z., Xiao, C., Huang, Y., Chen, M., Wei, W., Yang, X., Zhou, H., Bi, X., Lu, L., Ruan, J. and Fan, X., Enhanced bioactivity and osteoinductivity of carboxymethyl chitosan /nanohydroxyapatite /graphene oxide nanocomposites, RSC Adv., 8(32), 17860–17877 (2018).
https://doi.org/10.1039/C8RA00383A
Zhang, K., Hu, R., Fan, G. and Li, G., Graphene oxide/chitosan nanocomposite coated quartz crystal microbalance sensor for detection of amine vapors, Sens. Actuators B Chem., 243, 721–730 (2017).
https://doi.org/10.1016/j.snb.2016.12.063
Zhao, X., Wei, Z., Zhao, Z., Miao, Y., Qiu, Y., Yang, W., Jia, X., Liu, Z. and Hou, H., Design and development of graphene oxide nanoparticle/chitosan hybrids showing pH-sensitive surface charge-reversible ability for efficient intracellular doxorubicin delivery, ACS Appl. Mater. Interf., 10(7), 6608–6617 (2018).
https://doi.org/10.1021/acsami.7b16910
Zhao, X., Zou, X. and Ye, L., Controlled pH- and glucose-responsive drug release behavior of cationic chitosan-based nanocomposite hydrogels by using graphene oxide as drug nanocarrier, J. Ind. Eng. Chem., 49, 36–45 (2017).
