Open Access

Synthesis, Charecterization and Biological Activities Of N-(3-Methyl-2, 6-Diphenyl-Piperidin-4-Ylidine)-N-Phenyl-Hydrazine

P. Rajesh, p-rajesh124@yahoo.co.in
Department of Chemistry, Government Arts College (Autonomous), Coimbatore, TN, India. M. Dinesh Kumar, p-rajesh124@yahoo.co.in
Department of Chemistry, Government Arts College (Autonomous), Coimbatore, TN, India. R. Sathish Kumar, p-rajesh124@yahoo.co.in
Department of Botany, PSG College of Arts and Science, Coimbatore, TN, India R. Jamunarani p-rajesh124@yahoo.co.in
Department of Chemistry, Government Arts College (Autonomous), Coimbatore, TN, India.

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Abstract

In the present study a new 2,6-diphenyl-3-methyl-4-piperidone was prepared by Mannich reaction (condensation) of ethyl methyl ketone, aromatic aldehyde and ammonium acetate. N-(3-Methyl-2,6-diphenyl-piperidin-4-ylidine)-N’-phenyl-hydrazine was synthesized by reaction with sodium acetate in water and phenyl hydrazine. The chemical structures were confirmed by means of IR, 1H & 13C NMR spectral data. The compound was screened for acute anticancer, cytotoxicity, antibacterial and antifungal activities and their derivatives also having the same potent activities. The compound exhibited potent antibacterial activity against Proteus vulgaris and the better antifungal activity against Aspergillus flavus.

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