Open Access

Anhydrous ZnCl2 Catalyzed Synthesis of 2 Aryl Substituted Benzimidazole Derivatives

V. Mohanraj, chemistrymohan@gmail.com
Department of chemistry, Sri Ramakrishna mission Vidyalaya College of Arts and Science, Coimbatore, TN, India.
V. Murugesan, Department of chemistry, Sri Ramakrishna mission Vidyalaya College of Arts and Science, Coimbatore, TN, India. A. Karthik, Department of chemistry, Sri Ramakrishna mission Vidyalaya College of Arts and Science, Coimbatore, TN, India. B. Aravindan Department of chemistry, Sri Ramakrishna mission Vidyalaya College of Arts and Science, Coimbatore, TN, India.


J. Environ. Nanotechnol., Volume 3, No 1 (2014) pp. 48-52

https://doi.org/10.13074/jent.2014.01.132055

PDF


Abstract

Anhydrous ZnCl2 was used to be a catalyst for the synthesis of 2-arylsubstituted benzimidazoles efficiently. In this method is very simple convenient procedure, easy purification and shorter reaction time. So we prepared the many benzimidazole derivatives from this method. All the synthesized compounds were characterize d melting point, IR, 1H NMR, 13C NMR spectral data conformed the structure of the newly synthesized compounds.

Full Text

Reference


Jones, R. C. F. and Nichols, J. R., Thiamineco enzyme models: Imidazoliniumylides and there actions of 2 -(hydroxyalkyl) imidazolines, Tetrahedron Lett., 31, 1771-1774 (1990).

http://dx.doi.org/10.1016/S0040-4039(00)88877-2

Grimmet, M. R., A. R. Katcizky , C. W., Ress, E. F. and Sriven, Comprehensive Heterocyclic chemistry, Edn. Pergamon, Oxford, 3, 77 (1996).

Preston, P. N. and Stevens, M. F. G., Benzimidazoles and congeneric Tricyclic compounds Part2, JohnWiley & Sons, NewYork, 1980.

Kanazawa, C., Kamijo, S. and Yamamoto, Y., Synthesis of Imidazoles through the Copper-Catalyzed Cross Cyclo addition between Two Different Isocyanides, J. Am. Chem., Soc., 128, 10662-10663 (2006).

http:// dx.doi.org/10.1021/ja0617439

Gracias, V. , Gasiecki , A. F . S.and Djuric , W., Synthesis of Fused Bicyclic Imidazoles by Sequential Van Leusen/ Ring-Closing Meta thesis Reactions, organic lett., 7, 3183-3186 (2005).

http://dx.doi.org/10.1021/ol050852

Siddiqui, S. A., Narkhede, U. C., Palimkar, S. S., Daniel, T., Lahoti, R. J., Srinivasan, K. V., Room temperature ionic liquid promoted improved and rapid synthesis of 2,4,5-triaryl imidazoles from aryl aldehydes and 1,2-diketones or α-hydroxyketone, Tetrahedron., 61, 3539-3546 (2005).

http://dx.doi.org/10.1016/j.tet.2005.01.116

Tamm, I. and Sehgal, P. B., Halobenzimidazoleribosides and RNA synthesis of cells and viruses, Adv. Virus Res., 22, 187-258 (1978).

http://dx.doi.org/10.1016/S0065- 3527(08)60775-7

Contact Us

Powered by

Powered by OJS