Synthesis of 2-Methyl -3,4,5,10-Tetrahydro-Pyrrolo [3,2-A] Carbazole-Ethyl Carboxylate Derivatives and Evaluation of their Binding Affinity with CT-DNA
Received: 26-07-2013 | Accepted: 24-12-2013 | Published: 30-12-2013
J. Environ. Nanotechnol., Volume 2, No 4 (December 2013) pp. 62-67
Abstract
A new class of heterocyclic compound, substituted 2-methyl-3,4,5,10-tetarahydro-pyrrolo[3,2- a]carbazole-1-ethyl carboxylate derivatives have been prepared from 1-oxo-1,2,3,4,-tetrahydrocarbazoles. The structural features were determined by analytical and spectral techniques. DNA binding study of the compounds was investigated by absorption titration experiments which indicated that the compounds showed good binding affinity to CT-DNA via intercalation.
