Giloy Mediated Copper Nanoparticles: Their Bioactive Components, Medicinal Properties, and Species-Specific Antibacterial Efficacy
J. Environ. Nanotechnol., Volume 13, No 4 (2024) pp. 438-447
Abstract
This study used Tinospora cordifolia (Giloy), rich in bioactive compounds such as berberine and giloin, to synthesize copper nanoparticles (CuNPs). The CuNPs were characterized by UV-Vis spectrophotometry, showing a prominent absorption peak at 320 nm with an absorbance of 0.971. FTIR analysis confirmed stabilization by polyphenols and proteins, while X-ray diffraction (XRD) revealed 18 crystalline peaks. Scanning electron microscopy (SEM) showed agglomerated particles with sizes below 100 nm. The antibacterial efficacy of the CuNPs was tested against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. K. pneumoniae exhibited significant sensitivity at a minimum inhibitory concentration of 125 µg/ml, while other strains showed resistance. These findings suggest that T. cordifolia-mediated CuNPs could serve as targeted antibacterial agents, especially for multidrug-resistant K. pneumoniae, offering eco-friendly and sustainable applications in infection control and biomedical fields.
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