Nano-Titanium Dioxide: Antioxidant Activity and Cytotoxicity Against Human Lung Cancer Cell Line
J. Environ. Nanotechnol., Volume 13, No 1 (2024) pp. 254-261
Abstract
The scope of this study is to synthesize titanium dioxide nanoparticles by chemical method and to assess their antioxidant and anticancer properties. Titanium isopropoxide was employed as a precursor in the production of the nanoparticles of titanium dioxide. The sample was analyzed using a variety of characterization techniques, including X-ray diffraction, Ultraviolet-Visible Spectroscopy, Fourier Transform Infrared Spectroscopy, Field Emission Scanning Electron Microscopy, Energy Dispersive X-ray analysis. Further, their antioxidant and anticancer activities have been investigated. The crystallite size of titanium dioxide nanoparticles was revealed by X-ray diffraction, and the functional groups were confirmed by Fourier Transform Infrared Spectroscopy. Field emission scanning electron microscopy and energy dispersive X-ray analysis reveal the structure of the nanoparticles and the presence of titanium, carbon, and oxygen molecules, respectively. The antioxidant activity indicates that as the concentration of the TiO2 nanoparticles increases, it reaches the activity of ascorbic acid (standard). The sample shows good cytotoxic effect against A549 human lung cancer cell lines.
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