Open Access

Synthesis of 2-Methyl -3,4,5,10-Tetrahydro-Pyrrolo [3,2-A] Carbazole-Ethyl Carboxylate Derivatives and Evaluation of their Binding Affinity with CT-DNA

M. Saravanabhavan, Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, TN, India. V. Murugesan, Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, TN, India. M. Sekar mmsekar7@gmail.com
Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, TN, India.

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Abstract

A new class of heterocyclic compound, substituted 2-methyl-3,4,5,10-tetarahydro-pyrrolo[3,2- a]carbazole-1-ethyl carboxylate derivatives have been prepared from 1-oxo-1,2,3,4,-tetrahydrocarbazoles. The structural features were determined by analytical and spectral techniques. DNA binding study of the compounds was investigated by absorption titration experiments which indicated that the compounds showed good binding affinity to CT-DNA via intercalation.

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Reference

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